Diethyl malonate factory

Diethyl malonate, also known as dicarbethoxymethane or ethyl propanedioate, belongs to the class of organic compounds known as dicarboxylic acids and derivatives. These are organic compounds containing exactly two carboxylic acid groups. Diethyl malonate is an extremely weak basic (essentially neutral) compound (based on its pKa). Diethyl malonate is a sweet, apple, and fruity tasting compound. Outside of the human body, Diethyl malonate has been detected, but not quantified in, a few different foods, such as alcoholic beverages, evergreen blackberries, and fruits. This could make diethyl malonate a potential biomarker for the consumption of these foods. Like other esters, this compound undergoes bromination at the alpha position. 

Fischer esterification gives diethyl malonate:One of the principal uses of this compound is in the malonic ester synthesis. It occurs naturally in grapes and strawberries as a colourless liquid with an apple-like odour, and is used in perfumes. Malonic acid is a rather simple dicarboxylic acid, with two the carboxyl groups close together. The hydrogen atoms on a carbon adjacent to two carbonyl groups are even more acidic because the carbonyl groups help stabilize the carbanion resulting from the removal of a proton from the methylene group between them. Like many other esters, this compound undergoes the Claisen ester condensations. This alkylated 1,3-dicarbonyl compound readily undergoes decarboxylation with loss of carbon dioxide, to give a substituted acetic acid:Sodium ethoxide is preferred as the base. The use of aqueous sodium hydroxide may give the base hydrolysis products: sodium malonate and ethanol.

Diethyl malonate is used in organic synthesis for the preparation of alpha-aryl malonates, mono-substituted and di-substituted acetic acid, barbiturates and artificial flavorings. It is also involved in the synthesis of pharmaceuticals like chloroquine, butazolidin and barbital. It acts as intermediate in the synthesis of vitamin B1, vitamin B6, non-steroidal anti-inflammatory agents agrochemicals and perfumes. In Knoevenagel condensation reaction, it reacts with benzaldehyde to get diethyl benzylidenemalonate.

Chemwill Asia co.,Ltd is one of the leading factory of Organic compounds in CHINA.We own GMP licence as well
as ISO certificate paper. CHemwill employs over 165 peoples including professional technical experts and
professional-trained workers. The sales volume of our company in 2018 is over 8.5 million dollars. Our main
production base is located in Xuzhou industry park. We produce a wide range of organics including Active
pharmaceutical ingredients(APIs), Veterinary,  Indole derivatives, Aromatics, Fluorine, Boronic acids,organocatalysts,
chiral building blocks, heterocyclic compounds. We are certified both to the ISO 9001 and ISO 14001 Standards,
have a safety management system in place. If you need, please contact us.

Diethyl malonate factory

http://www.chemwillchina.com/Products/ProductsDetails-147.html