2-Chloronicotinic acid factory

2-chloronicotinic acid factory

2-Chloronicotinic acid is a derivative of nicotinic acid which is an important pharmaceutical

intermediates. 2-Chloronicotinic acid and its derivatives are commonly used in the synthesis

of pranoprofen and diflufenican[8-9].With the domestic and foreign scientific research institutions

effort to niacin derivatives, the application of the product is now not limited to the field of medicine,

and in the food, feed, dyeslight, heat additives and other field also has application. Therefore, the

development of nicotinic acid derivatives with better bioactivity has become a hotspot in the field of

medicine.

2-Chloronicotinic acid and its derivatives are important intermediates for the synthesis of medical antibiotics, anti-cardiovascular drugs, insecticides and herbicides, and they used in the synthesis pranoprofen and diflufenican. In this work, a rapid synthetic method for 2-morpholinonicotinic acid was established. The 2-morpholinonicotinic acid was synthesized from the commercially available 2-chloronicotinic acid through three steps including esterification, nucleophilic substitution and hydrolysis. The structures were confirmed by MS. Furthermore, the synthetic method was optimized, and the total yield of the three steps was 93 %.

Product Name	:	2-Chloronicotinic acid
Synonyms	:	2-Chloropyridine-3-carboxylic acid
CAS Number	:	2942-59-8
Molecular Formula	:	C6H4CINO2
Molecular Wt.	:	157.55
Specification Compliance	:	In-House Specification
Description	:	White to almost white powder
Applications	:	2-Chloropyridine-3-carboxylic acid was used in the preparation of 2-pyridyl 2-chloropyridine-3-carboxylate, inpharmaceuticals and agriculture

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2021/9/11

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2-Chloronicotinic acid factory

2-chloronicotinic acid factory