Meldrumic acid;2,2-Dimethyl-1,3-dioxane-4,6-dione factory

Propylene diacid ring (sub) isopropylene can be used as a pharmaceutical synthetic intermediate, can be prepared by the reaction of propylene diacid and acetic anhydride. Propylene diacid (sub) isopropyl esters can be used to prepare compounds 3-oxygen-4-phenylpropylene ethyl ester, and further preparation of 3,4-di-replacement-6-benzene ethyl ketone-type HIV-1 reverse transcriptase inhibitors.

preparation
52g (0.5mol) propylene diacid dissolved in 60ml (0.6mol) acetic acid, added 1.5ml concentrated sulphuric acid under ice water cooling, 10min after drop plus 40ml (0.5) 5mol) of acetone, after stirring for 15min in ice bath conditions, rose to room temperature, placed the mixture in the refrigerator overnight, decompression filtered white solid propylene diacid (sub) isopropyl ester, acetone-ice water recrystallization, yield 72.2%. mp: 95 to 96 degrees C (document value 94 to 95 degrees C)
Meldrumic?acid;2,2-Dimethyl-1,3-dioxane-4,6-dione 2033-24-1 manufacturer (chemwillchina.com)